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Specialty adhesive labels easily adhere to the plastic substrates and curved surfaces of pens and auto-injectors, devices increasingly used by patients, such as diabetics, for self-injection. These new injection systems are growing in popularity due to the user comfort and patient safety features that they can offer. Feature detachable label segments to assure proper documentation of drug dispensing and administration, labels with tactile elements such as Braille or elements to ensure safe handling of the injection system and tamper-evident solutions to reliably indicate first opening of a pen or auto-injector.